| Homer Simpson/Grampa/Barney Gumble/Krusty the Klown/Groundskeeper Willie/Mayor Quimby/Hans Moleman/S | | Dan Castellaneta (voice) |
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| Bart Simpson/Nelson Muntz/Todd Flanders/Ralph Wiggum/Kearney/Others | | Nancy Cartwright (voice) |
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| Marge Simpson/Patty & Selma Bouvier/Others | | Julie Kavner (voice) |
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| Lisa Simpson | | Yeardley Smith (voice) |
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| Moe Szyslak/Chief Wiggum/Apu/Comic Book Guy/Cletus/Prof. Frink/Others | | Hank Azaria (voice) |
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| Montgomery Burns/Waylon Smithers/Ned Flanders/Kent Brockman/Rev. Lovejoy/Principal Skinner/Dr. Hibbe | | Harry Shearer (voice) |
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| Edna Krabappel (1990-) | | Marcia Wallace (voice) |
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| Lionel Hutz/Troy McClure (1991-1998) | | Phil Hartman (voice) |
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| Jimbo Jones/Agnes Skinner/Others | | Tress MacNeille (voice) |
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| Milhouse Van Houten/Rod Flanders/Others | | Pamela Hayden (voice) |
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| Maude Flanders/Helen Lovejoy/Others (1990-1999, 2002-) | | Maggie Roswell (voice) |
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| Martin Prince/Others (1990-) | | Russi Taylor (voice) |
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| Lunchlady Doris (1989-1996) | | Doris Grau (voice) |
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| Additional Voices (1998-) | | Karl Wiedergott (voice) |
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| Maude Flanders/Helen Lovejoy/Others (1999-2002) | | Marcia Mitzman Gaven (voice) |
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